Theres nothing there.). Im not going to make the same mistake again.. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. Always be self aware when using fluvoxamine. Hes now outlived his initial prognosis by several years. Its all about NIH saying it is OK. . As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. It works best when it is given early, as soon as symptoms start. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Repurposed drugs are safer and more effective than the current vaccines. A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Fluvoxamine is also an Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. Lack of action. While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to. See this Wall Street Journal op-ed. Here's why. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. more time. customer-service@technologyreview.com with a list of newsletters youd like to receive. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Has it really been 25 years, a whole quarter of a century? Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. A very short op-ed arguing for using fluvoxamine against COVID. It's hard to ignore this lecture in explaining why the drug is so effective. 21. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. (article I did after the TOGETHER trial). The study was also featured on 60 Minutes. Online. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. Another CETF grant, though, yielded far more exciting results. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. We didnt come up with better mouse technology than Microsoft did. One is to reduce the threat of nuclear war. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. The. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). And not zero., Kirsch immediately forwarded the exchange to me and, I suspect, other journalists. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Some people report mild nausea while on the drug (stops when stop the drug). Now weve lost the high ground, Morris told me. Its the gold standard of medical evidence. People are dying. A very short op-ed arguing for using fluvoxamine against COVID. MisinformationKills. I learned this the hard way. Steve Kirsch is baffled. . Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. There were no studies reported out so far where fluvoxamine made things worse or neutral. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. He prefers iconoclastic approaches, whether by directly funding asteroid detection or advocating for nuclear power to combat global warming. 19 In addition, several . The combined p value of the two studies is <.0001. There were no studies reported out so far where fluvoxamine made things worse or neutral. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. All can merit a fluvoxamine prescription based on traditional diagnoses. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. The web price charge of skirsch.io . How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. My favorite dosage is 50mg twice a day for 14 days. P-value was 10^-14 on that study (done by Dr. That was a lie. This document is a collection of evidence that highlights the glaring errors in our pandemic response. The FDA approved Molnupiravir which was less effective. We asked Steve to tone it down. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Online Status. The NIH wrote a bullshit rejection because the FDA told them not to approve it. The medical community did nothing (with a few exceptions like Dr. Seftel). It could do nothing. (Clayton Fox, Marty Makary, and Jeffrey Klausner). My crime? In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. That way you can start immediately. So much for evidence-based medicine. Its motivated out of his sense of keeping people safe and advancing health care.. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. 36m "We found Fauci was the most highly compensated federal employee. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. Its not about the science. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. If you take fluvoxamine, please avoid caffeine while on the drug. He started 7 high tech companies, two with billion dollar market caps. He has been a medical philanthropist for more than 20 years. Were having trouble saving your preferences. The evidence is solid. (Siliciano did not respond to requests for comment for this article.). Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. They never make things worse so are safe to try. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. But fear of trying something new prevents any doctor from giving this drug a try. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Note that some of these articles are inaccurate. Fluoxetine is just as effective. reach out to us at The sooner you start, the better the outcomes. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. As noted before, the repository has a link to the 1 hour serotonin lecture. I think so. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Here are the key things you should know about fluvoxamine for COVID: It works. He has a history of giving away some of his millions to good causes, and when COVID-19 began. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. The track management was so impressed, they asked for prescriptions. I have never heard of a case it didn't work. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? The babys brain was split in half, and it was just covered with blood. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. 12:45 AM . - Quora, Heres presentation I gave at the re-open California Conference on January 9,2021: How to fix the problemHow to fix the problem Steve Kirsch Executive DirectorCOVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008Google Docs[https://docs.google.com/presentation/d/1-A4y78wv3tTPmVu57FOabY6j-MJbPwMGojKwZfaCkAs/. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. If you cant get a prescription for COVID, then perhaps you have OCD? Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. So it was both obvious and convincing the difference between the groups to the workers and the track management. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. ICER: From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). I fully expected both organizations to do absolutely nothing. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. For decades, coders wrote critical systems in C and C++. Links to evidence about fluvoxamine including the public data repository. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". Part of TV News Archive. Ive used it personally at 50mg twice a day and experience no adverse events at all. Proven in clinical use all over the world. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. He has made millions from these projects, even if they have not turned him into a household name. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Weve known it works since August 24, 2020. . It never was. But the potential upsides. We could have saved a lot of lives. It does not matter how many lives will be saved. If you cant lay off the java, then try fluoxetine (Prozac). including the very promising Fluvoxamine. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. It does not matter how many lives will be saved. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. Please read and agree to the disclaimer before watching this video.. Steve Kirsch On COVID Early Treatment and CensorshipSteve Kirsch is an entrepreneur and . The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. If you start later, doctors use higher dosages and compliance becomes a bigger problem. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. That study was featured on 60 Minutes. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. You will be wired for 24 hours if you dont heed my advice. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. All the medical journals refused to publish the meeting notes (rejected by 6 journals). For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. You cannot get any better than that. Get your prescription in advance of getting COVID. Those days are gone. If you take fluvoxamine, please avoid caffeine while on the drug. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. But Kirsch is also motivated by an unsatisfied competitive streak. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. Another is to identify an asteroid that is going to hit the planet.. What happens when your prescription drug becomes the center of covid misinformation. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. Steve put in $1MM of his own money and . He has been a medical philanthropist for more than 20 years. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Worst case, if we ignore all additional evidence so the average is a 60% pass rate. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. If you start later, doctors use higher dosages and compliance becomes a bigger problem. In-patient use. I fixed the link to the fluvoxamine article. Have the drug on hand. The data is there in plain sight for anyone to see today. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Avoid caffeine, benadryl, tylenol, and alcohol. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. JAMA systematic review and meta analysis It doesnt get any better than this. Design thinking was supposed to fix the world. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. It is perhaps the greatest unnecessary loss of life in American history. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? I took it myself at that dosage and noticed zero side effects. But even she was drained by Kirschs constant attempts to override the data. If you have trouble getting a prescription, perhaps you have OCD? Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. Im just telling you the truth. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. The infectious disease scientists lied to me. Food/drugs to avoid while on fluvoxamine. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. Your best bet is to. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. . Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). My website. I took it myself at that dosage and noticed zero side effects. Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. But not 150K. In severe cases, it takes longer. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. The NIH wrote a bullshit rejection because the FDA told them not to approve it. It doesnt get much better than that. But they dont want their names used. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. Why fluvoxamine isnt used. If you cant get a prescription for COVID, then perhaps you have OCD? So instead of this paper being treated as confirming an earlier hypothesis, it was treated as generating a novel hypothesis. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Three of the four outpatient trials have been reported out: all were successful. May 16, 2022. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. Physicians who use the drug for COVID now swear by it. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. The sooner you start, the better the outcomes. . Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. February 17, 2021. . Medium revoked my account for life. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. He was recently featured on 60 Minutes, . Some speaker, off camera, went on a . Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. My experience is very typical. Twenty-four years ago, . Note that some of these articles are inaccurate. They left their recommendation of fluvoxamine at NEUTRAL. With cases spiking, the Los Angeles area banned gatherings. 33. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. Silence from the medical community. This looks ominous, but it harmless. Dr. Eric Lenze: So the results were really pretty. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora Proxalutamide and fluvoxamine pushers and the early treatment grift. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. The 5 observational studies is icing on the cake. These people never called the researchers whose trials they claimed showed no effect. Stopping the meds will return you to your normal self. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. Ive used it personally at 50mg twice a day and experience no adverse events at all. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. 90,000 people don't have to die in the next 3 weeks. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. Zero. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Hes very convincing. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. This is what the Seftel trial at Golden Gate fields used. Some countries dont have fluvoxamine so this is the alternative. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Then he hosted a superspreader event. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. . Its whether Merck can make a killing that matters. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. The drug was FDA-approved more than 65 years ago. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. See this. Timing is everything with respect to outcomes. The differences are obvious to untrained eyes. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. I couldn't agree more. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet.